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Metabolomic and sphingolipidomic profiling of human hepatoma cells exposed to widely used pharmaceuticals.

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第一作者： Miriam,Pérez-Cova

第一单位： Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, Barcelona E08034, Spain; Department of Chemical Engineering and Analytical Chemistry, University of Barcelona, Diagonal 647, Barcelona, Barcelona E08028, Spain.

作者： Miriam,Pérez-Cova ^[1] ; Carmen,Bedia ^[2] ; Antonio,Checa ^[3] ; Isabel,Meister ^[4] ; Romà,Tauler ^[2] ; Craig E,Wheelock ^[5] ; Joaquim,Jaumot ^[6]

作者单位： Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, Barcelona E08034, Spain; Department of Chemical Engineering and Analytical Chemistry, University of Barcelona, Diagonal 647, Barcelona, Barcelona E08028, Spain. ^[1] Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, Barcelona E08034, Spain. ^[2] Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden. ^[3] Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden; Gunma University Initiative for Advanced Research (GIAR), Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. ^[4] Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden; Gunma University Initiative for Advanced Research (GIAR), Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm 141-86, Sweden. ^[5] Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, Barcelona E08034, Spain. Electronic address: joaquim.jaumot@idaea.csic.es. ^[6]

关键词 HepG2 cells Low-dose Metabolomics Pharmaceuticals Sphingolipids