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首页> Stem cell research & therapy> Insulin promotes the bone formation capability of human dental pulp stem cells through attenuating the IIS/PI3K/AKT/mTOR pathway axis.

Insulin promotes the bone formation capability of human dental pulp stem cells through attenuating the IIS/PI3K/AKT/mTOR pathway axis.

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作者： Lingling,E ^[1] ; Yanbo,Shan ^[1] ; Yuxi,Luo ^[1] ; Lin,Feng ^[1] ; Yawen,Dai ^[1] ; Mingzhu,Gao ^[1] ; Yan,Lv ^[1] ; Chaoran,Zhang ^[1] ; Hongchen,Liu ^[1] ; Ning,Wen ^[2] ; Rong,Zhang ^[3]

作者单位： Institute of Stomatology & Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing, China. ^[1] Institute of Stomatology & Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing, China. wenningchn@163.com. ^[2] Institute of Stomatology & Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing, China. techiezhang@163.com.;Department of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China. techiezhang@163.com. ^[3]

关键词 Bone regeneration Human dental pulp stem cells Insulin Insulin/insulin-like growth factor-1 signaling (IIS) pathway PI3K/AKT/mTOR pathway

主题词牙髓(Dental Pulp);人类(Humans);骨生成(Osteogenesis);胰岛素(Insulin);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);干细胞(Stem Cells);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);细胞增殖(Cell Proliferation);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);细胞分化(Cell Differentiation);信号传导(Signal Transduction);小鼠(Mice);动物(Animals);硬羟基磷灰石(Durapatite);细胞, 培养的(Cells, Cultured);胰岛素样生长因子Ⅰ(Insulin-Like Growth Factor I);胶原(Collagen)

DOI 10.1186/s13287-024-03843-9

PMID 39075596

发布时间 2024-09-06

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Stem cell research & therapy

Stem cell research & therapy

2024年15卷1期

227页

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