换一批
换一批SIRT1 silencing promotes EMT and Crizotinib resistance by regulating autophagy through AMPK/mTOR/S6K signaling pathway in EML4-ALK L1196M and EML4-ALK G1202R mutant non-small cell lung cancer cells.
第一作者：
Qian,Yang
第一单位：
Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, Shenhe District, China.
作者：
主题词
人类(Humans);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);抗衰老酶1(Sirtuin 1);肺肿瘤(Lung Neoplasms);抗药性, 肿瘤(Drug Resistance, Neoplasm);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);癌基因蛋白质类, 融合(Oncogene Proteins, Fusion);自噬(Autophagy);信号传导(Signal Transduction);上皮-间质转化(Epithelial-Mesenchymal Transition);细胞系, 肿瘤(Cell Line, Tumor);突变(Mutation);AMP活化蛋白激酶类(AMP-Activated Protein Kinases);细胞增殖(Cell Proliferation);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);动物(Animals);细胞运动(Cell Movement);小鼠(Mice)
DOI
10.1002/mc.23799
PMID
39078281
发布时间
2024-10-10
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Molecular carcinogenesis
2133-2144页
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