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Genome wide association study of clinical duration and age at onset of sporadic CJD.

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第一作者： Holger,Hummerich

第一单位： MRC Prion Unit at University College London (UCL), Institute of Prion Diseases, UCL, London, United Kingdom.

作者： Holger,Hummerich ^[1] ; Helen,Speedy ^[1] ; Tracy,Campbell ^[1] ; Lee,Darwent ^[1] ; Elizabeth,Hill ^[1] ; Steven,Collins ^[2] ; Christiane,Stehmann ^[2] ; Gabor G,Kovacs ^[3] ; Michael D,Geschwind ^[4] ; Karl,Frontzek ^[5] ; Herbert,Budka ^[6] ; Ellen,Gelpi ^[6] ; Adriano,Aguzzi ^[5] ; Sven J,van der Lee ^[7] ; Cornelia M,van Duijn ^[8] ; Pawel P,Liberski ^[9] ; Miguel,Calero ^[10] ; Pascual,Sanchez-Juan ^[11] ; Elodie,Bouaziz-Amar ^[12] ; Jean-Louis,Laplanche ^[12] ; Stéphane,Haïk ^[13] ; Jean-Phillipe,Brandel ^[13] ; Angela,Mammana ^[14] ; Sabina,Capellari ^[15] ; Anna,Poleggi ^[16] ; Anna,Ladogana ^[16] ; Maurizio,Pocchiari ^[16] ; Saima,Zafar ^[17] ; Stephanie,Booth ^[18] ; Gerard H,Jansen ^[19] ; Aušrinė,Areškevičiūtė ^[20] ; Eva,Løbner Lund ^[21] ; Katie,Glisic ^[22] ; Piero,Parchi ^[15] ; Peter,Hermann ^[23] ; Inga,Zerr ^[23] ; Brian S,Appleby ^[22] ; Jiri,Safar ^[24] ; Pierluigi,Gambetti ^[24] ; John,Collinge ^[1] ; Simon,Mead ^[1]

作者单位： MRC Prion Unit at University College London (UCL), Institute of Prion Diseases, UCL, London, United Kingdom. ^[1] Australian National Creutzfeldt-Jakob Disease Registry, The Florey, Department of Medicine (RMH), The University of Melbourne, Victoria, Australia. ^[2] Department of Laboratory Medicine and Pathobiology and Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Ontario, Toronto, Canada.;Laboratory Medicine Program & Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.;Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna and Austrian Reference Center for Human Prion Diseases (ÖRPE), Vienna, Austria. ^[3] UCSF Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, United States of America. ^[4] Institute of Neuropathology, University of Zürich, Zürich, Switzerland. ^[5] Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna and Austrian Reference Center for Human Prion Diseases (ÖRPE), Vienna, Austria. ^[6] Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.;Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands.;Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands. ^[7] Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.;Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands. ^[8] Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland. ^[9] Chronic Disease Programme (UFIEC-CROSADIS) and Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. ^[10] Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, Madrid, Spain. ^[11] Department of Biochemistry and Molecular Biology, Lariboisière Hospital, GHU AP-HP Nord, University of Paris Cité, Paris, France. ^[12] Paris Brain Institute (Institut du Cerveau, ICM), INSERM, CNRS, Assistance Publique-Hôpitaux de Paris (AP-HP), Sorbonne Université, Paris, France.;Assistance Publique-Hôpitaux de Paris (AP-HP), Cellule Nationale de Référence des Maladies de Creutzfeldt-Jakob, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. ^[13] IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy. ^[14] IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.;Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. ^[15] Department of Neuroscience, Istituto Superiore di Sanità, Rome, Italy. ^[16] Department of Neurology, Clinical Dementia Center and National Reference Center for CJD Surveillance, University Medical School, Göttingen, Germany.;Biomedical Engineering and Sciences Department, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology, Islamabad, Pakistan. ^[17] Prion Disease Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada. ^[18] Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada. ^[19] Danish Reference Center for Prion Diseases, Department of Pathology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. ^[20] Danish Reference Center for Prion Diseases, Department of Pathology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. ^[21] National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, OH, United States of America. ^[22] Department of Neurology, Clinical Dementia Center and National Reference Center for CJD Surveillance, University Medical School, Göttingen, Germany.;German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany. ^[23] Departments of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States of America. ^[24]