The deubiquitinase OTUD1 stabilizes NRF2 to alleviate hepatic ischemia/reperfusion injury.

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第一作者： Qi,Zhang

第一单位： Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan, 430068, China.

作者： Qi,Zhang ^[1] ; Zihan,Chen ^[2] ; Jinglei,Li ^[3] ; Kunpeng,Huang ^[3] ; Zhihao,Ding ^[4] ; Biao,Chen ^[3] ; Tianxing,Ren ^[3] ; Peng,Xu ^[3] ; Guoliang,Wang ^[5] ; Hongji,Zhang ^[6] ; Xiao-Dong,Zhang ^[7] ; Jinxiang,Zhang ^[8] ; Hui,Wang ^[9]

作者单位： Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan, 430068, China. ^[1] Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. ^[2] Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. ^[3] Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, China. ^[4] Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. ^[5] Department of Surgery, University of Virginia, Charlottesville, VA, 22903, USA. ^[6] Hengyang Medical School, University of South China, Hengyang, 421001, China. ^[7] Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: zhangjinxiang@hust.edu.cn. ^[8] Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: wanghuipitt@hust.edu.cn. ^[9]

关键词 Deubiquitination ETGE peptides Hypoxia/oxygenation OTU deubiquitinase 1 Oxidative stress

主题词动物(Animals);人类(Humans);男(雄)性(Male);小鼠(Mice);细胞凋亡(Apoptosis);疾病模型, 动物(Disease Models, Animal);肝(Liver);NF-E2相关因子2(NF-E2-Related Factor 2);氧化性应激(Oxidative Stress);再灌注损伤(Reperfusion Injury);泛素化(Ubiquitination)

DOI 10.1016/j.redox.2024.103287

PMID 39079388

发布时间 2024-09-19

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Redox biology

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The deubiquitinase OTUD1 stabilizes NRF2 to alleviate hepatic ischemia/reperfusion injury.

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The deubiquitinase OTUD1 stabilizes NRF2 to alleviate hepatic ischemia/reperfusion injury.

Redox biology

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Redox biology

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