Combined diosmin and bisoprolol attenuate cobalt chloride-induced cardiotoxicity and endothelial dysfunction through modulating miR-143-3P/MAPK/MCP-1, ERK5/CXCR4, Orai-1/STIM-1 signaling pathways.

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作者： Ehab A M,El-Shoura ^[1] ; Ahmed A N,Mohamed ^[2] ; Ahmed M,Atwa ^[3] ; Esraa A,Salem ^[4] ; Souty M Z,Sharkawi ^[5] ; Hend,Mostafa Selim ^[6] ; Aya,Ibrahim Elberri ^[7] ; El-Sayed,Gawesh ^[8] ; Yasmine H,Ahmed ^[9] ; Omnia A M,Abd El-Ghafar ^[10]

作者单位： Clinical Pharmacy Department, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt. ^[1] Medical Pharmacology Department, Al-Azhar University, Assuit, Egypt. ^[2] Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt. ^[3] Department of Clinical Physiology, Faculty of Medicine, Menoufia University, Shebeen ElKom, 32511, Egypt. ^[4] Pharmacology and Toxicology Department, Beni Suef University, Beni Suef, Egypt. ^[5] Biochemistry Department, Faculty of Pharmacy, Tanta University, Egypt. ^[6] Genetic Engineering and Molecular Biology Division, Department of Zoology, Faculty of Science, Menoufia University, Shebeen Elkom 32511, Egypt. ^[7] Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Al-Azhar University, Damietta, Egypt. ^[8] Department of Cytology and Histology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt. ^[9] Pharmacology and Toxicology Department, Nahda University, Beni Suef, Egypt. ^[10]

关键词 Acute myocardial injury Bisoprolol CoCl2 Diosmin Hypobaric hypoxia pathway