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首页> Journal of translational medicine> Suppression of NUPR1 in fibroblast-like synoviocytes reduces synovial fibrosis via the Smad3 pathway.

Suppression of NUPR1 in fibroblast-like synoviocytes reduces synovial fibrosis via the Smad3 pathway.

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作者： Taiyang,Liao ^[1] ; Lei,Shi ^[1] ; Chenglong,He ^[1] ; Deren,Liu ^[1] ; Yibao,Wei ^[1] ; Zhenyuan,Ma ^[1] ; Peimin,Wang ^[2] ; Jun,Mao ^[3] ; Peng,Wu ^[4]

作者单位： Department of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Chinese Medicine/Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, Jiangsu, China.;Key Laboratory for Metabolic Diseases in Chinese Medicine, First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu, China. ^[1] Department of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Chinese Medicine/Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, Jiangsu, China. ^[2] Department of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Chinese Medicine/Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, Jiangsu, China. maojun@njucm.edu.cn. ^[3] Department of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Chinese Medicine/Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, Jiangsu, China. wupeng@njucm.edu.cn. ^[4]

关键词 Knee osteoarthritis Nuclear protein 1 Smad family member 3 Synovial fibrosis Transforming growth factor beta

主题词动物(Animals);Smad3蛋白质(Smad3 Protein);纤维化(Fibrosis);成纤维细胞(Fibroblasts);信号传导(Signal Transduction);小鼠, 近交C57BL(Mice, Inbred C57BL);滑膜(Synovial Membrane);男(雄)性(Male);骨关节炎, 膝(Osteoarthritis, Knee);疾病模型, 动物(Disease Models, Animal);小鼠(Mice);碱性螺旋-环-螺旋转录因子类(Basic Helix-Loop-Helix Transcription Factors);DNA结合蛋白质类(DNA-Binding Proteins);肿瘤蛋白质类(Neoplasm Proteins)

DOI 10.1186/s12967-024-05540-w

PMID 39090667

发布时间 2024-08-04

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Journal of translational medicine

Journal of translational medicine

2024年22卷1期

715页

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