Polystyrene nanoplastics induce apoptosis, autophagy, and steroidogenesis disruption in granulosa cells to reduce oocyte quality and fertility by inhibiting the PI3K/AKT pathway in female mice.

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第一作者： Yue,Xue

第一单位： School of Basic Medical Sciences and School of Public and Jiangxi Provincial Key Laboratory of Preventive Medicine, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.

作者： Yue,Xue ^[1] ; Xiu,Cheng ^[2] ; Zhang-Qiang,Ma ^[2] ; Hou-Peng,Wang ^[2] ; Chong,Zhou ^[1] ; Jia,Li ^[1] ; Da-Lei,Zhang ^[2] ; Liao-Liao,Hu ^[3] ; Yan-Fan,Cui ^[4] ; Jian,Huang ^[1] ; Tao,Luo ^[5] ; Li-Ping,Zheng ^[6]

作者单位： School of Basic Medical Sciences and School of Public and Jiangxi Provincial Key Laboratory of Preventive Medicine, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. ^[1] School of Basic Medical Sciences and School of Public and Jiangxi Provincial Key Laboratory of Preventive Medicine, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.;Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang, 330006, China. ^[2] The 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. ^[3] School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China. ^[4] School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China. luotao@ncu.edu.cn.;Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang, 330006, China. luotao@ncu.edu.cn. ^[5] School of Basic Medical Sciences and School of Public and Jiangxi Provincial Key Laboratory of Preventive Medicine, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. Zhengliping@ncu.edu.cn.;Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang, 330006, China. Zhengliping@ncu.edu.cn. ^[6]

关键词 Apoptosis Autophagy Oocyte quality PI3K/AKT signaling pathway Polystyrene nanoplastics