Discovery of novel amide derivatives against VEGFR-2/tubulin with potent antitumor and antiangiogenic activity.

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作者： Zhenling,Liu ^[1] ; Shuqiang,Mao ^[2] ; Huixia,Li ^[1] ; Wei,Liu ^[1] ; Jing,Tao ^[1] ; Yuebing,Lu ^[1] ; Hui,Dong ^[1] ; Jie,Zhang ^[3] ; Chuanjun,Song ^[4] ; Yongtao,Duan ^[5] ; Yongfang,Yao ^[6]

作者单位： Henan Provincial Key Laboratory of Pediatric Hematology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou 450018, China. ^[1] College of Chemistry, Zhengzhou University, Zhengzhou 450001, China. ^[2] Henan Provincial Key Laboratory of Pediatric Hematology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou 450018, China. Electronic address: stzhangj@263.net. ^[3] College of Chemistry, Zhengzhou University, Zhengzhou 450001, China. Electronic address: chjsong@zzu.edu.cn. ^[4] Henan Provincial Key Laboratory of Pediatric Hematology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou 450018, China. Electronic address: duanyongtao860409@163.com. ^[5] Henan Provincial Key Laboratory of Pediatric Hematology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou 450018, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China. Electronic address: yongfangyao@zzu.edu.cn. ^[6]

关键词 Structure-activity relation (SAR)Tubulin Tumor VEGFR-2