Glucosylceramide synthase modulation ameliorates murine renal pathologies and promotes macrophage effector function in vitro.

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第一作者： Agnes,Cheong

第一单位： Rare and Neurologic Diseases Research, Sanofi, Cambridge, MA, USA. agnes.cheong@sanofi.com.

作者： Agnes,Cheong ^[1] ; Florin,Craciun ^[2] ; Hervé,Husson ^[2] ; Joseph,Gans ^[3] ; Javier,Escobedo ^[2] ; Yi-Chien,Chang ^[3] ; Lilu,Guo ^[3] ; Mariana,Goncalves ^[3] ; Nathan,Kaplan ^[4] ; Laurie A,Smith ^[4] ; Sarah,Moreno ^[4] ; Joseph,Boulanger ^[5] ; Shiguang,Liu ^[6] ; Jacqueline,Saleh ^[4] ; Mindy,Zhang ^[3] ; Anna S,Blazier ^[4] ; Weiliang,Qiu ^[7] ; Andrew,Macklin ^[4] ; Tejaswi,Iyyanki ^[8] ; Clément,Chatelain ^[8] ; Shameer,Khader ^[8] ; Thomas A,Natoli ^[4] ; Oxana,Ibraghimov-Beskrovnaya ^[4] ; Dimitry,Ofengeim ^[4] ; Jonathan D,Proto ^[9]

作者单位： Rare and Neurologic Diseases Research, Sanofi, Cambridge, MA, USA. agnes.cheong@sanofi.com. ^[1] Genomics Medicine Unit, Sanofi, Waltham, MA, USA. ^[2] Translational Sciences, Sanofi, Cambridge, MA, USA. ^[3] Rare and Neurologic Diseases Research, Sanofi, Cambridge, MA, USA. ^[4] Research and Development Business Office, Sanofi, Cambridge, MA, USA. ^[5] Rare Diseases and Rare Blood Disorders Research, Sanofi, Cambridge, MA, USA. ^[6] Non-Clinical Efficacy & Safety, Sanofi, Cambridge, MA, USA. ^[7] Precision Medicine and Computational Biology, Sanofi, Cambridge, MA, USA. ^[8] Rare and Neurologic Diseases Research, Sanofi, Cambridge, MA, USA. jproto@neurocrine.com. ^[9]

主题词动物(Animals);巨噬细胞(Macrophages);小鼠(Mice);葡糖转移酶类(Glucosyltransferases);小鼠, 基因敲除(Mice, Knockout);小鼠, 近交C57BL(Mice, Inbred C57BL);疾病模型, 动物(Disease Models, Animal);肾(Kidney);男(雄)性(Male)

DOI 10.1038/s42003-024-06606-7

PMID 39095617

发布时间 2024-12-19

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Communications biology

2024年7卷1期

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Glucosylceramide synthase modulation ameliorates murine renal pathologies and promotes macrophage effector function in vitro.

Communications biology

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Glucosylceramide synthase modulation ameliorates murine renal pathologies and promotes macrophage effector function in vitro.

Communications biology

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Communications biology

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