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Machine learning-driven diagnosis of multiple sclerosis from whole blood transcriptomics.

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第一作者： Maryam,Omrani

第一单位： Institute of Experimental Neurology and Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.

作者： Maryam,Omrani ^[1] ; Rosaria Rita,Chiarelli ^[1] ; Massimo,Acquaviva ^[1] ; Claudia,Bassani ^[1] ; Gloria,Dalla Costa ^[2] ; Federico,Montini ^[2] ; Paolo,Preziosa ^[2] ; Lucia,Pagani ^[3] ; Francesca,Grassivaro ^[4] ; Simone,Guerrieri ^[5] ; Marzia,Romeo ^[5] ; Francesca,Sangalli ^[5] ; Bruno,Colombo ^[5] ; Lucia,Moiola ^[5] ; Mauro,Zaffaroni ^[6] ; Anna,Pietroboni ^[7] ; Alessandra,Protti ^[8] ; Marco,Puthenparampil ^[4] ; Roberto,Bergamaschi ^[9] ; Giancarlo,Comi ^[2] ; Maria A,Rocca ^[2] ; Vittorio,Martinelli ^[5] ; Massimo,Filippi ^[2] ; Cinthia,Farina ^[10]

作者单位： Institute of Experimental Neurology and Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy. ^[1] Institute of Experimental Neurology and Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Unit of Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. ^[2] IQVIA, Analytics Center of Excellence, Milano. ^[3] Dipartimento di Neuroscienze, Azienda Ospedale - Università di Padova, Padova, Italy. ^[4] Institute of Experimental Neurology and Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Unit of Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy. ^[5] Centro Sclerosi Multipla, ASST della Valle Olona, Ospedale di Gallarate, Gallarate, Italy. ^[6] Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy. ^[7] ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy. ^[8] IRCCS Fondazione Mondino, Pavia, Italy. ^[9] Institute of Experimental Neurology and Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: farina.cinthia@hsr.it. ^[10]

关键词 Biomarkers Clinically isolated syndrome Machine learning Multiple sclerosis RNAseq Whole blood