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首页> Molecular and cellular neurosciences> β<sub>2</sub>-adrenoceptor agonist formoterol attenuates NLRP3 inflammasome activation and GSDMD-mediated pyroptosis in microglia through enhancing IκBα/NF-κB inhibition, SQSTM1/p62-dependent selective autophagy and ESCRT-III-mediated plasma membrane repair.

β<sub>2</sub>-adrenoceptor agonist formoterol attenuates NLRP3 inflammasome activation and GSDMD-mediated pyroptosis in microglia through enhancing IκBα/NF-κB inhibition, SQSTM1/p62-dependent selective autophagy and ESCRT-III-mediated plasma membrane repair.

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作者： Mehmet,Erdem ^[1] ; Şeniz,Erdem ^[2] ; Ahmet,Alver ^[3] ; Tuğba Raika,Kıran ^[4] ; Süleyman Caner,Karahan ^[3]

作者单位： Department of Medical Biochemistry, Faculty of Medicine, Malatya Turgut Özal University, Malatya 44900, Turkey; Department of Medical Biochemistry, Graduate School of Medical Science, Karadeniz Technical University, Trabzon 61080, Turkey. Electronic address: mehmet.erdem@ozal.edu.tr. ^[1] Department of Medical Biochemistry, Graduate School of Medical Science, Karadeniz Technical University, Trabzon 61080, Turkey; Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey. ^[2] Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey. ^[3] Department of Medical Biochemistry, Faculty of Medicine, Malatya Turgut Özal University, Malatya 44900, Turkey. ^[4]

关键词 Autophagy ESCRT-III-mediated plasma membrane repair Formoterol Microglia NLRP3 inflammasome Pyroptosis

主题词小神经胶质细胞(Microglia);动物(Animals);小鼠(Mice);NF-κB(NF-kappa B);炎性体(Inflammasomes);自噬(Autophagy);肾上腺素能β-2受体激动剂(Adrenergic beta-2 Receptor Agonists);细胞膜(Cell Membrane);磷酸结合蛋白质类(Phosphate-Binding Proteins);细胞系(Cell Line)

DOI 10.1016/j.mcn.2024.103956

PMID 39097250

发布时间 2024-09-23

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Molecular and cellular neurosciences

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