Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome.

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作者： Antti J,Luikku ^[1] ; Ossi,Nerg ^[2] ; Anne M,Koivisto ^[3] ; Tuomo,Hänninen ^[2] ; Antti,Junkkari ^[4] ; Susanna,Kemppainen ^[5] ; Sini-Pauliina,Juopperi ^[5] ; Rosa,Sinisalo ^[5] ; Alli,Pesola ^[6] ; Hilkka,Soininen ^[7] ; Mikko,Hiltunen ^[5] ; Ville,Leinonen ^[1] ; Tuomas,Rauramaa ^[8] ; Henna,Martiskainen ^[5]

作者单位： Institute of Clinical Medicine-Neurosurgery, University of Eastern Finland, Kuopio, Finland.;Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland. ^[1] Neurology of NeuroCenter, Kuopio University Hospital, Kuopio, Finland.;Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland. ^[2] Neurology of NeuroCenter, Kuopio University Hospital, Kuopio, Finland.;Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland.;Department of Neurosciences, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.;Department of Geriatrics/Rehabilitation and Internal Medicine, University of Helsinki, Helsinki University Hospital, Helsinki, Finland. ^[3] Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland. ^[4] Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. ^[5] Institute of Clinical Medicine-Neurosurgery, University of Eastern Finland, Kuopio, Finland. ^[6] Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland. ^[7] Department of Pathology, Kuopio University Hospital, Kuopio, Finland.;Institute of Clinical Medicine-Pathology, University of Eastern Finland, Kuopio, Finland. ^[8]

关键词 Alzheimer disease beta amyloid brain biopsy cognition convoluted neural network deep learning dementia microglia normal pressure hydrocephalus