Novel pleuromutilin derivatives conjugated with phenyl-sulfide and boron-containing moieties as potent antibacterial agents against antibiotic-resistant bacteria.

导出 LinkOut

翻译打印收藏纠错

作者： Xinyu,Luo ^[1] ; Guangxu,Wu ^[2] ; Jing,Feng ^[1] ; Jie,Zhang ^[1] ; Hengjian,Fu ^[2] ; Hang,Yu ^[1] ; Zunsheng,Han ^[1] ; Wansen,Nie ^[3] ; Zihao,Zhu ^[1] ; Bo,Liu ^[1] ; Weidong,Pan ^[2] ; Beibei,Li ^[3] ; Yan,Wang ^[1] ; Chi,Zhang ^[1] ; Tianlei,Li ^[4] ; Wenxuan,Zhang ^[5] ; Song,Wu ^[6]

作者单位： State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of New Drug Research and Development, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. ^[1] State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China. ^[2] Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, 200241, China. ^[3] State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of New Drug Research and Development, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: litianlei818@163.com. ^[4] State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of New Drug Research and Development, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: wxzhang@imm.ac.cn. ^[5] State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of New Drug Research and Development, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: ws@imm.ac.cn. ^[6]

关键词 Antimicrobial resistance Conjugated compounds MRSA Pleuromutilin derivatives Pleuromutilin-resistant strain