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A CRISPR/RfxCas13d-mediated strategy for efficient RNA knockdown in mouse embryonic development.

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第一作者： Lin,Zhang

第一单位： State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.

作者： Lin,Zhang ^[1] ; Shi-Meng,Cao ^[2] ; Hao,Wu ^[2] ; Meng,Yan ^[1] ; Jinsong,Li ^[3] ; Ling-Ling,Chen ^[4]

作者单位： State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. ^[1] Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. ^[2] State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. jsli@sibcb.ac.cn.;Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China. jsli@sibcb.ac.cn.;School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. jsli@sibcb.ac.cn. ^[3] Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. linglingchen@sibcb.ac.cn.;Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China. linglingchen@sibcb.ac.cn.;School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. linglingchen@sibcb.ac.cn.;New Cornerstone Science Laboratory, Shenzhen, 518054, China. linglingchen@sibcb.ac.cn. ^[4]

关键词 CRISPR-RfxCas13d RNA knockdown embryonic development semi-cloned technology sperm-like stem cell