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mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies.

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第一作者： Javier,Guenaga

第一单位： Wyatt Lab, Department of Immunology and Microbiology, Scripps Research, La Jolla, CA, United States.

作者： Javier,Guenaga ^[1] ; Mehrdad,Alirezaei ^[1] ; Yu,Feng ^[1] ; Mohamad-Gabriel,Alameh ^[2] ; Wen-Hsin,Lee ^[3] ; Sabyasachi,Baboo ^[4] ; Jocelyn,Cluff ^[1] ; Richard,Wilson ^[1] ; Shridhar,Bale ^[1] ; Gabriel,Ozorowski ^[3] ; Paulo,Lin ^[5] ; Ying,Tam ^[5] ; Jolene K,Diedrich ^[6] ; John R,Yates ^[6] ; James C,Paulson ^[7] ; Andrew B,Ward ^[8] ; Drew,Weissman ^[9] ; Richard T,Wyatt ^[10]

作者单位： Wyatt Lab, Department of Immunology and Microbiology, Scripps Research, La Jolla, CA, United States. ^[1] Weissman Lab, Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.;Weissman Lab, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. ^[2] Ward Lab, Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, United States. ^[3] Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research, La Jolla, CA, United States. ^[4] Acuitas Therapeutics, Vancouver, BC, Canada. ^[5] Paulson Lab, Department of Molecular Medicine, Scripps Research, La Jolla, CA, United States. ^[6] Wyatt Lab, Department of Immunology and Microbiology, Scripps Research, La Jolla, CA, United States.;Paulson Lab, Department of Molecular Medicine, Scripps Research, La Jolla, CA, United States. ^[7] Ward Lab, Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, United States.;Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research, La Jolla, CA, United States. ^[8] Weissman Lab, Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.;Weissman Lab, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. ^[9] Wyatt Lab, Department of Immunology and Microbiology, Scripps Research, La Jolla, CA, United States.;Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research, La Jolla, CA, United States. ^[10]

关键词 HIV Env NFL SOSIP immunogenicity mRNA vaccine