Structure-activity relationships of thiadiazole agonists of the human secretin receptor.

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第一作者： Robert,Ardecky

第一单位： From Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address: rardecky@sbpdiscovery.org.

作者： Robert,Ardecky ^[1] ; Daniela G,Dengler ^[2] ; Kaleeckal G,Harikumar ^[3] ; Mathew M,Abelman ^[2] ; Jiwen,Zou ^[2] ; Bryan A,Kramer ^[2] ; Santhi Reddy,Ganji ^[2] ; Steve,Olson ^[2] ; Alina,Ly ^[2] ; Nikhil,Puvvula ^[2] ; Chen-Ting,Ma ^[2] ; Raghuveer,Ramachandra ^[2] ; Eduard A,Sergienko ^[4] ; Laurence J,Miller ^[5]

作者单位： From Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address: rardecky@sbpdiscovery.org. ^[1] From Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. ^[2] Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, USA. ^[3] From Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address: esergien@sbpdiscovery.org. ^[4] Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, USA. Electronic address: miller@mayo.edu. ^[5]

关键词 G protein-coupled receptor Secretin receptor Small molecule agonist Structure-activity relationships

主题词人类(Humans);构效关系(Structure-Activity Relationship);噻二唑类(Thiadiazoles);受体, 胃肠激素(Receptors, Gastrointestinal Hormone);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);动物(Animals);CHO细胞(CHO Cells);仓鼠属(Cricetulus);微粒体, 肝(Microsomes, Liver)

DOI 10.1016/j.slasd.2024.100176

PMID 39122117

发布时间 2025-01-30

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SLAS discovery

2024年29卷6期

100176页

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Structure-activity relationships of thiadiazole agonists of the human secretin receptor.

SLAS discovery

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Structure-activity relationships of thiadiazole agonists of the human secretin receptor.

SLAS discovery

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SLAS discovery

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