Synthesis, Computational Study, and In Vitro α-Glucosidase Inhibitory Action of Thiourea Derivatives Based on 3-Aminopyridin-2(1<i>H</i>)-Ones.

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作者： Zarina,Shulgau ^[1] ; Irina,Palamarchuk ^[2] ; Shynggys,Sergazy ^[1] ; Assel,Urazbayeva ^[1] ; Alexander,Gulyayev ^[1] ; Yerlan,Ramankulov ^[3] ; Ivan,Kulakov ^[4]

作者单位： National Laboratory Astana, Nazarbayev University, Kabanbai Batyr Ave. 53, Astan Z05H0P9, Kazakhstan.;National Center for Biotechnology, 13/5 Kurgalzhynskoe Road, Astana Z05K8D5, Kazakhstan. ^[1] School of Natural Sciences, Tyumen State University, 15a Perekopskaya St., Tyumen 625003, Russia. ^[2] School of Science and Technology, Nazarbayev University, Kabanbai Batyr Ave. 53, Astana Z05H0P9, Kazakhstan. ^[3] National Laboratory Astana, Nazarbayev University, Kabanbai Batyr Ave. 53, Astan Z05H0P9, Kazakhstan.;School of Natural Sciences, Tyumen State University, 15a Perekopskaya St., Tyumen 625003, Russia. ^[4]

关键词 3-aminopyridin-2(1H)-ones IC50 antidiabetic activity isothiocyanates molecular docking thiourea derivatives α-glucosidase inhibition

主题词硫脲(Thiourea);α葡糖苷酶类(alpha-Glucosidases);构效关系(Structure-Activity Relationship);降血糖药(Hypoglycemic Agents);分子结构(Molecular Structure);氨基吡啶类(Aminopyridines)

DOI 10.3390/molecules29153627

PMID 39125032

发布时间 2024-09-18

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