REACT: a randomized trial to assess the efficacy and safety of clazosentan for preventing clinical deterioration due to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

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第一作者： Stephan A,Mayer

第一单位： 1Neurocritical Care and Emergency Neurological Services, Westchester Medical Center Health Network, Valhalla, New York.;2Department of Neurology and Neurosurgery, New York Medical College, New York, New York.

作者： Stephan A,Mayer ^[1] ; Nicolas,Bruder ^[2] ; Giuseppe,Citerio ^[3] ; Luc,Defreyne ^[4] ; Cecile,Dubois ^[5] ; Rajiv,Gupta ^[6] ; Randall,Higashida ^[7] ; Angelina,Marr ^[8] ; Thanh N,Nguyen ^[9] ; Sébastien,Roux ^[8] ; Martin,Smrčka ^[10] ; Ramon Torné,Torné ^[11] ; E François,Aldrich ^[12] ; on behalf of the REACT investigators

作者单位： 1Neurocritical Care and Emergency Neurological Services, Westchester Medical Center Health Network, Valhalla, New York.;2Department of Neurology and Neurosurgery, New York Medical College, New York, New York. ^[1] 3Department of Anesthesia and Critical Care, CHU Timone, APHM, Aix-Marseille University, Marseille, France. ^[2] 4School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. ^[3] 5Department of Interventional Radiology and Neuroradiology, Ghent University, Ghent, Belgium. ^[4] 6Biometry, Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland. ^[5] 7Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Massachusetts. ^[6] 8Department of Radiology, Division of Neurointerventional Radiology, University of California, San Francisco Medical Center, San Francisco, California. ^[7] 9Global Clinical Development, Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland. ^[8] 10Department of Neurology, Neurosurgery, and Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, Massachusetts. ^[9] 11Department of Neurosurgery, University Hospital Brno, Czechia. ^[10] 12Department of Neurosurgery, Hospital Clinic of Barcelona, Spain; and. ^[11] 13Department of Neurosurgery, University of Maryland, Baltimore, Maryland. ^[12]

关键词 aneurysm cerebral ischemia cerebral vasospasm clazosentan endothelin-1 subarachnoid hemorrhage vascular disorders