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Revealing the impact of modified modules flexibility on gemcitabine prodrug nanoassemblies for effective cancer therapy.

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第一作者： Jiayu,Guo

第一单位： Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

作者： Jiayu,Guo ^[1] ; Xiaoxiao,Zhang ^[1] ; Fudan,Dong ^[2] ; Simeng,Wang ^[1] ; Danping,Wang ^[1] ; Yaqiao,Li ^[3] ; Shiyi,Zuo ^[4] ; Qing,Wang ^[1] ; Wenxiao,Li ^[1] ; Jin,Sun ^[5] ; Zhonggui,He ^[5] ; Tianhong,Zhang ^[5] ; Qikun,Jiang ^[6] ; Bingjun,Sun ^[7]

作者单位： Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China. ^[1] Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, China. ^[2] Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. ^[3] Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia. ^[4] Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang 110016, China. ^[5] Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang 110016, China. Electronic address: jiangqk_student@aliyun.com. ^[6] Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang 110016, China. Electronic address: sunbingjun_spy@sina.com. ^[7]

关键词 Antitumor therapy Flexibility Gemcitabine Modification modules Prodrug nanoassemblies