Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals.

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作者： Giovanni,Pascarella ^[1] ; Kayla N,Conner ^[2] ; Noah J,Goff ^[3] ; Piero,Carninci ^[4] ; Andrew J,Olive ^[2] ; Katheryn,Meek ^[5]

作者单位： RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan. Electronic address: kmeek@msu.edu. ^[1] Department of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI 48824, USA. ^[2] Department of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI 48824, USA; Department of Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA. ^[3] RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan; Human Technopole, Milan, Italy. ^[4] Department of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI 48824, USA; Department of Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA. Electronic address: kmeek@msu.edu. ^[5]

关键词 DNA dependent protein kinase (DNA-PK)DNA-PK catalytic subunit (DNA-PKcs)Non-allelic homologous recombination (NAHR)Non-homologous end joining (NHEJ)