Distinct conformational states enable transglutaminase 2 to promote cancer cell survival versus cell death.

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作者： Cody,Aplin ^[1] ; Kara A,Zielinski ^[2] ; Suzette,Pabit ^[2] ; Deborah,Ogunribido ^[3] ; William P,Katt ^[4] ; Lois,Pollack ^[2] ; Richard A,Cerione ^[5] ; Shawn K,Milano ^[1]

作者单位： Department of Chemistry and Chemical Biology, Cornell University, 14853, Ithaca, NY, USA.;Department of Molecular Medicine, Cornell University, 14853, Ithaca, NY, USA. ^[1] School of Applied and Engineering Physics, Cornell University, 14853, Ithaca, NY, USA. ^[2] Department of Chemistry and Chemical Biology, Cornell University, 14853, Ithaca, NY, USA. ^[3] Department of Molecular Medicine, Cornell University, 14853, Ithaca, NY, USA. ^[4] Department of Chemistry and Chemical Biology, Cornell University, 14853, Ithaca, NY, USA. rac1@cornell.edu.;Department of Molecular Medicine, Cornell University, 14853, Ithaca, NY, USA. rac1@cornell.edu. ^[5]

主题词人类(Humans);GTP结合蛋白质类(GTP-Binding Proteins);转谷酰胺酶(Transglutaminases);蛋白质构象(Protein Conformation);细胞存活(Cell Survival);冷冻电子显微镜检查(Cryoelectron Microscopy);细胞系, 肿瘤(Cell Line, Tumor);细胞死亡(Cell Death);散射, 小角(Scattering, Small Angle);X线衍射(X-Ray Diffraction);钙(Calcium)

DOI 10.1038/s42003-024-06672-x

PMID 39134806

发布时间 2024-12-20

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Communications biology

2024年7卷1期

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Distinct conformational states enable transglutaminase 2 to promote cancer cell survival versus cell death.

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Distinct conformational states enable transglutaminase 2 to promote cancer cell survival versus cell death.

Communications biology

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Communications biology

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