Metabolic activation of WHO-congeners PCB28, 52, and 101 by human CYP2A6: evidence from in vitro and in vivo experiments.

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作者： Isabella,Randerath ^[1] ; Thomas,Schettgen ^[1] ; Julian Peter,Müller ^[2] ; Jens,Rengelshausen ^[1] ; Susanne,Ziegler ^[3] ; Nathalia,Quinete ^[4] ; Jens,Bertram ^[1] ; Salah,Laieb ^[1] ; Elke,Schaeffeler ^[5] ; Andrea,Kaifie ^[1] ; Katja S,Just ^[2] ; Aaron,Voigt ^[6] ; Roman,Tremmel ^[5] ; Matthias,Schwab ^[7] ; Julia C,Stingl ^[2] ; Thomas,Kraus ^[1] ; Patrick,Ziegler ^[8]

作者单位： Institute for Occupational, Social and Environmental Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. ^[1] Institute of Clinical Pharmacology, University Hospital of RWTH, 52074, Aachen, Germany. ^[2] Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany. ^[3] Department of Chemistry and Biochemistry, Institute of Environment, Florida International University, 3000 NE 151s Street, North Miami, FL, 33181, USA. ^[4] Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Tübingen, Germany. ^[5] Department of Neurology, University Medical Center, RWTH Aachen University, 52074, Aachen, Germany. ^[6] Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Tübingen, Germany.;Departments of Clinical Pharmacology, and Pharmacy and Biochemistry, University of Tuebingen, Tübingen, Germany. ^[7] Institute for Occupational, Social and Environmental Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. pziegler@ukaachen.de. ^[8]

关键词 CYP2A6 Carcinogenesis Cytochrome p450 monooxygenase Polychlorinated biphenyls