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Prosapogenin A induces GSDME-dependent pyroptosis of anaplastic thyroid cancer through vacuolar ATPase activation-mediated lysosomal over-acidification.

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作者: Yunye,Liu [1] ; Yawen,Guo [2] ; Qian,Zeng [3] ; Yiqun,Hu [2] ; Ru,He [1] ; Wenli,Ma [4] ; Chenhong,Qian [5] ; Tebo,Hua [6] ; Fahuan,Song [2] ; Yefeng,Cai [7] ; Lei,Zhu [8] ; Xinxin,Ren [2] ; Jiajie,Xu [2] ; Chuanming,Zheng [2] ; Lingling,Ding [1] ; Jingyan,Ge [3] ; Wenzhen,Wang [3] ; Haifeng,Xu [9] ; Minghua,Ge [10] ; Guowan,Zheng [11]
作者单位: Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China. [1] Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.;Zhejiang Key Laboratory of Precision Medicine Research on Head & Neck Cancer, Hangzhou, China.;Zhejiang Provincial Clinical Research Center for malignant tumor, Hangzhou, Zhejiang, China. [2] Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China. [3] Bengbu Medical College, Bengbu, Anhui, China. [4] The Second Affiliated Hospital of Jiaxing University, Jiaxing, China. [5] Department of Thyroid Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China. [6] Department of Thyroid Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. [7] Department of Thyroid Surgery, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui City, Zhejiang Province, China. [8] Department of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. [9] Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China. geminghua@hmc.edu.cn.;Zhejiang Key Laboratory of Precision Medicine Research on Head & Neck Cancer, Hangzhou, China. geminghua@hmc.edu.cn.;Zhejiang Provincial Clinical Research Center for malignant tumor, Hangzhou, Zhejiang, China. geminghua@hmc.edu.cn. [10] Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China. guowan.zheng@ki.se.;Zhejiang Key Laboratory of Precision Medicine Research on Head & Neck Cancer, Hangzhou, China. guowan.zheng@ki.se.;Zhejiang Provincial Clinical Research Center for malignant tumor, Hangzhou, Zhejiang, China. guowan.zheng@ki.se. [11]
DOI 10.1038/s41419-024-06985-z
PMID 39138191
发布时间 2024-09-20
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