Identification of Novel Antileishmanial Chemotypes By High-Throughput Virtual and In Vitro Screening.

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第一作者： Huma,Khan

第一单位： Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan, Pakistan.

作者： Huma,Khan ^[1] ; Mohammed Ageeli,Hakami ^[2] ; Mubarak A,Alamri ^[3] ; Bader S,Alotaibi ^[2] ; Nazif,Ullah ^[4] ; Rasool,Khan ^[5] ; Asaad,Khalid ^[6] ; Ashraf N,Abdalla ^[7] ; Abdul,Wadood ^[8]

作者单位： Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan, Pakistan. ^[1] Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra Univesity, Al-Quwayiyah-19257, Riyadh, Saudi Arabia. ^[2] Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia. ^[3] Department of Biotechnology, Abdul Wali Khan University Mardan, Mardan, Pakistan. ^[4] Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan. ^[5] Substance Abuse and Toxicology Research Center, Jazan University, P.O. Box: 114, 45142, Jazan, Saudi Arabia. akahmed@jazanu.edu.sa. ^[6] Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, 21955, Makkah, Saudi Arabia. ^[7] Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan, Pakistan. awadood@awkum.edu.pk. ^[8]

关键词 Leishmania Chemotypes Docking Simulation Trypanothione reductase Trypanothione synthetase Virtual screening