Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization.

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作者： Anna,Bonomini ^[1] ; Tommaso,Felicetti ^[2] ; Martina,Pacetti ^[2] ; Chiara,Bertagnin ^[1] ; Alice,Coletti ^[2] ; Federica,Giammarino ^[3] ; Marta,De Angelis ^[4] ; Federica,Poggialini ^[5] ; Antonio,Macchiarulo ^[2] ; Stefano,Sabatini ^[2] ; Beatrice,Mercorelli ^[1] ; Lucia,Nencioni ^[4] ; Ilaria,Vicenti ^[3] ; Elena,Dreassi ^[5] ; Violetta,Cecchetti ^[2] ; Oriana,Tabarrini ^[2] ; Arianna,Loregian ^[6] ; Serena,Massari ^[7]

作者单位： Department of Molecular Medicine, University of Padua, 35121, Padua, Italy. ^[1] Department of Pharmaceutical Sciences, University of Perugia, 06123, Perugia, Italy. ^[2] Department of Medical Biotechnologies, University of Siena, 53100, Siena, Italy. ^[3] Department of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185, Rome, Italy. ^[4] Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100, Siena, Italy. ^[5] Department of Molecular Medicine, University of Padua, 35121, Padua, Italy. Electronic address: arianna.loregian@unipd.it. ^[6] Department of Pharmaceutical Sciences, University of Perugia, 06123, Perugia, Italy. Electronic address: serena.massari@unipg.it. ^[7]

主题词抗病毒药(Antiviral Agents);人类(Humans);动物(Animals);构效关系(Structure-Activity Relationship);病毒蛋白质类(Viral Proteins);分子结构(Molecular Structure);蛋白质多聚化(Protein Multimerization);剂量效应关系, 药物(Dose-Response Relationship, Drug);流感病毒A型(Influenza A virus);微生物敏感性试验(Microbial Sensitivity Tests);狗(Dogs)

DOI 10.1016/j.ejmech.2024.116737

PMID 39153334

发布时间 2024-09-10

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European journal of medicinal chemistry

2024年277卷

116737页

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Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization.

European journal of medicinal chemistry

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European journal of medicinal chemistry

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Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization.

European journal of medicinal chemistry

相似文献

European journal of medicinal chemistry

相关期刊

检索历史清除