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Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.

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作者单位: Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada. [1] Division of Genetics, Department of Medicine, University of California, San Diego, San Diego, CA, USA; Department of Cellular and Molecular Medicine, Stem Cell Program, Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA. [2] New York Genome Center, New York, NY, USA; Department of Biology, New York University, New York, NY, USA. [3] Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [4] Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Center, Montreal General Hospital, Montreal, QC, Canada. [5] Department of Physiology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada. [6] McGill Genome Center and Department of Human Genetics, McGill University, Montreal, QC, Canada. [7] Department of Cellular and Molecular Medicine, Stem Cell Program, Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA. [8] Division of Genetics, Department of Medicine, University of California, San Diego, San Diego, CA, USA. Electronic address: tideker@ucsd.edu. [9] Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada. Electronic address: yang.zhou7@mcgill.ca. [10]
DOI 10.1016/j.celrep.2024.114637
PMID 39154337
发布时间 2025-01-22
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