CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant.

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作者： Samuel Joseph,Kaplan ^[1] ; Wilfred,Wong ^[2] ; Jielin,Yan ^[3] ; Julian,Pulecio ^[4] ; Hyein S,Cho ^[4] ; Qianzi,Li ^[2] ; Jiahui,Zhao ^[5] ; Jayanti,Leslie-Iyer ^[4] ; Jonathan,Kazakov ^[4] ; Dylan,Murphy ^[5] ; Renhe,Luo ^[3] ; Kushal K,Dey ^[6] ; Effie,Apostolou ^[7] ; Christina S,Leslie ^[6] ; Danwei,Huangfu ^[8]

作者单位： Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY 10065, USA; Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[1] Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY 10065, USA; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[2] Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[3] Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[4] Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY 10065, USA. ^[5] Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[6] Meyer Cancer Center, Division of Neuro-Oncology, Department of Neurology, Sandra and Edward Meyer Cancer Center, New York-Presbyterian Hospital/Weill Cornell Medicine, New York, NY 10065, USA. ^[7] Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: huangfud@mskcc.org. ^[8]

关键词 CP: Developmental biology CP: Molecular biology CRISPRi screen ONECUT1 T2D VUS enhancer neonatal diabetes non-coding variant pancreas development type 2 diabetes variant of uncertain significance

主题词人类(Humans);增强子元件, 遗传学(Enhancer Elements, Genetic);细胞分化(Cell Differentiation);胰腺(Pancreas);糖尿病, 2型(Diabetes Mellitus, Type 2);多潜能干细胞(Pluripotent Stem Cells);GATA6转录因子(GATA6 Transcription Factor)

DOI 10.1016/j.celrep.2024.114640

PMID 39163202

发布时间 2025-01-22

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