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Synthesis, in vitro, and in silico study of novel pyridine based 1,3-diphenylurea derivatives as tyrosinase inhibitors.

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第一作者： Anam,Rubbab Pasha

第一单位： Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan; Natural and Medical Sciences Research Centre, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Oman.

作者： Anam,Rubbab Pasha ^[1] ; Majid,Khan ^[2] ; Ajmal,Khan ^[3] ; Javid,Hussain ^[4] ; Mariya,Al-Rashida ^[5] ; Talha,Islam ^[5] ; Zahra,Batool ^[6] ; Hamdy,Kashtoh ^[7] ; Magda H,Abdellattif ^[8] ; Ahmed,Al-Harrasi ^[9] ; Zahid,Shafiq ^[6] ; Silvia,Schenone ^[10]

作者单位： Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan; Natural and Medical Sciences Research Centre, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Oman. ^[1] Natural and Medical Sciences Research Centre, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Oman; Department of Biochemistry, Hazara University, Mansehra, Pakistan. ^[2] Natural and Medical Sciences Research Centre, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Oman. ^[3] Department of Biological Sciences and Chemistry, University of Nizwa, Oman. ^[4] Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan. ^[5] Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. ^[6] Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Gyeongbuk, Republic of Korea. Electronic address: hamdy_kashtoh@ynu.ac.kr. ^[7] Chemistry Department, College of Sciences, University College of Taraba, Taif University, Taif 21944, Saudi Arabia. ^[8] Natural and Medical Sciences Research Centre, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Oman. Electronic address: aharrasi@unizwa.edu.om. ^[9] Department of Pharmacy, University of Genoa, Viale Benedetto XV, 3, Genoa 16132, Italy. Electronic address: silvia.schenone@unige.it. ^[10]

关键词 1,3-diphenylurea Docking MD simulation Pyridine Tyrosinase