ADAM10 isoforms: Optimizing usage of antibodies based on protein regulation, structural features, biological activity and clinical relevance to Alzheimer's disease.

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第一作者： Sabrina,Dorta

第一单位： Department of Gerontology, Federal University of São Carlos, São Carlos, SP, Brazil.

作者： Sabrina,Dorta ^[1] ; Vanessa,Alexandre-Silva ^[1] ; Cecilia Patricia,Popolin ^[1] ; Danilo Barroso,de Sousa ^[1] ; Marina Mantellatto,Grigoli ^[1] ; Lucas Nogueira de Carvalho,Pelegrini ^[1] ; Patricia Regina,Manzine ^[1] ; Antoni,Camins ^[2] ; Elena,Marcello ^[3] ; Kristina,Endres ^[4] ; Marcia Regina,Cominetti ^[5]

作者单位： Department of Gerontology, Federal University of São Carlos, São Carlos, SP, Brazil. ^[1] Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain; Institute of Neurosciences, Universitat de Barcelona, Barcelona, Catalonia, Spain. ^[2] Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", University of Milan, Milan, Italy. ^[3] Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. ^[4] Department of Gerontology, Federal University of São Carlos, São Carlos, SP, Brazil; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland. Electronic address: mcominetti@ufscar.br. ^[5]

关键词 A Disintegrin And Metalloproteinase 10 (ADAM10)Alzheimer’s disease Amyloid precursor protein (APP)Antibody Biomarker Isoforms Shedding

主题词人类(Humans);阿尔茨海默病(Alzheimer Disease);动物(Animals);蛋白质亚型(Protein Isoforms);淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);抗体(Antibodies);膜蛋白质类(Membrane Proteins)

DOI 10.1016/j.arr.2024.102464

PMID 39173916

发布时间 2024-11-01

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