首页> The Journal of pathology> Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease.

Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease.

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第一作者： Jennifer C,Chandler

第一单位： Developmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, UK.;UCL Centre for Kidney and Bladder Health, London, UK.

作者： Jennifer C,Chandler ^[1] ; Daniyal J,Jafree ^[2] ; Saif,Malik ^[1] ; Gideon,Pomeranz ^[1] ; Mary,Ball ^[1] ; Maria,Kolatsi-Joannou ^[1] ; Alice,Piapi ^[3] ; William J,Mason ^[1] ; Andrew V,Benest ^[4] ; David O,Bates ^[5] ; Aleksandra,Letunovska ^[6] ; Reem,Al-Saadi ^[6] ; Marion,Rabant ^[7] ; Olivia,Boyer ^[8] ; Kathy,Pritchard-Jones ^[3] ; Paul J,Winyard ^[1] ; Andrew S,Mason ^[9] ; Adrian S,Woolf ^[10] ; Aoife M,Waters ^[3] ; David A,Long ^[1]

作者单位： Developmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, UK.;UCL Centre for Kidney and Bladder Health, London, UK. ^[1] Developmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, UK.;UCL Centre for Kidney and Bladder Health, London, UK.;UCL MB/PhD Programme, Faculty of Medical Sciences, University College London, London, UK. ^[2] Developmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, UK. ^[3] Endothelial Quiescence Group and Tumour and Vascular Biology Laboratories, Division of Cancer and Stem Cells, Centre for Cancer Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK. ^[4] Endothelial Quiescence Group and Tumour and Vascular Biology Laboratories, Division of Cancer and Stem Cells, Centre for Cancer Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.;Pan-African Cancer Research Institute, University of Pretoria, Hatfield, South Africa. ^[5] Developmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, UK.;Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. ^[6] Pathology department, Hôpital Universitaire Necker-Enfants Malades, Institut Imagine, Université Paris Cité, Paris, France. ^[7] APHP, Service de Néphrologie Pédiatrique, Hôpital Universitaire Necker-Enfants Malades, Institut Imagine, Université Paris Cité, Paris, France. ^[8] Department of Biology and York Biomedical Research Institute, University of York, UK. ^[9] Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.;Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. ^[10]

关键词 WT1 glomerulopathy adrenomedullin childhood glomerular disease glomerular endothelium neuropilin‐1 podocyte single‐cell transcriptomics vascular endothelial growth factor‐A