CD4<sup>+</sup> and CD8<sup>+</sup> T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment.

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第一作者： Meenakshi,Kar

第一单位： Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.;Emory Vaccine Center, Emory University, Atlanta, GA, USA.;Emory National Primate Research Center, Atlanta, GA, USA.

作者： Meenakshi,Kar ^[1] ; Katherine E E,Johnson ^[2] ; Abigail,Vanderheiden ^[3] ; Elizabeth J,Elrod ^[4] ; Katharine,Floyd ^[1] ; Elizabeth,Geerling ^[5] ; E Taylor,Stone ^[5] ; Eduardo,Salinas ^[4] ; Stephanie,Banakis ^[2] ; Wei,Wang ^[2] ; Shruti,Sathish ^[2] ; Swathi,Shrihari ^[1] ; Meredith E,Davis-Gardner ^[1] ; Jacob,Kohlmeier ^[6] ; Amelia,Pinto ^[5] ; Robyn,Klein ^[7] ; Arash,Grakoui ^[4] ; Elodie,Ghedin ^[2] ; Mehul S,Suthar ^[8]

作者单位： Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.;Emory Vaccine Center, Emory University, Atlanta, GA, USA.;Emory National Primate Research Center, Atlanta, GA, USA. ^[1] Systems Genomics Section, Laboratory of Parasitic Diseases, DIR, NIAID, NIH, Bethesda, MD, USA. ^[2] Center for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.;Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. ^[3] Emory Vaccine Center, Emory University, Atlanta, GA, USA.;Emory National Primate Research Center, Atlanta, GA, USA.;Department of Medicine, Emory University School of Medicine, Emory University, Atlanta, GA, USA. ^[4] Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO, USA. ^[5] Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA. ^[6] Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, Western University, London, Ontario, Canada.;Schulich School of Medicine and Dentistry, Western Institute of Neuroscience, Western University, London, Ontario, Canada. ^[7] Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.;Emory Vaccine Center, Emory University, Atlanta, GA, USA.;Emory National Primate Research Center, Atlanta, GA, USA.;Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA. ^[8]

主题词动物(Animals);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);病毒复制(Virus Replication);肺(Lung);人类(Humans);女(雌)性(Female);鼻黏膜(Nasal Mucosa);颗粒酶类(Granzymes)

DOI 10.1126/sciadv.adp2636

PMID 39178263

发布时间 2024-08-27

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CD4<sup>+</sup> and CD8<sup>+</sup> T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment.

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CD4<sup>+</sup> and CD8<sup>+</sup> T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment.

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