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首页> Journal of hazardous materials> Identification of sanguinarine as a novel antagonist for perfluorooctanoate/perfluorooctane sulfonate-induced senescence of hepatocytes: An integrated computational and experimental analysis.

Identification of sanguinarine as a novel antagonist for perfluorooctanoate/perfluorooctane sulfonate-induced senescence of hepatocytes: An integrated computational and experimental analysis.

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作者： Xue,Zhang ^[1] ; Huan,Gao ^[1] ; Xiaoyu,Chen ^[1] ; Ziqi,Liu ^[1] ; Han,Wang ^[1] ; Mengxing,Cui ^[1] ; Yajie,Li ^[2] ; Yongjiang,Yu ^[1] ; Shen,Chen ^[1] ; Xiumei,Xing ^[1] ; Liping,Chen ^[1] ; Daochuan,Li ^[1] ; Xiaowen,Zeng ^[1] ; Qing,Wang ^[3]

作者单位： Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. ^[1] Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; Infinitus (China) Company Ltd, Guangzhou 510623, China. ^[2] Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: wangq27@mail.sysu.edu.cn. ^[3]

关键词 Cellular senescence Hepatotoxicity Screening antagonists Transcriptomics-based method mTOR-p53 pathway

主题词氟碳化合物(Fluorocarbons);肝细胞(Hepatocytes);辛酸盐类(Caprylates);人类(Humans);链烷磺酸类(Alkanesulfonic Acids);异喹啉类(Isoquinolines);苯并菲啶类(Benzophenanthridines);计算生物学(Computational Biology);动物(Animals);Hep G2细胞(Hep G2 Cells);信号传导(Signal Transduction)

DOI 10.1016/j.jhazmat.2024.135583

PMID 39180998

发布时间 2024-09-07

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Journal of hazardous materials

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