Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis.

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第一作者： Yousef,Dashti

第一单位： Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.;Sydney Infectious Diseases Institute, Faculty of Medicine and Health, University of Sydney, Sydney NSW 2015, Australia.

作者： Yousef,Dashti ^[1] ; Fatemeh,Mohammadipanah ^[2] ; Yu,Zhang ^[3] ; Pietra M,Cerqueira Diaz ^[3] ; Anthony,Vocat ^[4] ; Daniel,Zabala ^[3] ; Christopher D,Fage ^[3] ; Isolda,Romero-Canelon ^[5] ; Boyke,Bunk ^[6] ; Cathrin,Spröer ^[6] ; Lona M,Alkhalaf ^[3] ; Jörg,Overmann ^[7] ; Stewart T,Cole ^[4] ; Gregory L,Challis ^[8]

作者单位： Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.;Sydney Infectious Diseases Institute, Faculty of Medicine and Health, University of Sydney, Sydney NSW 2015, Australia. ^[1] Pharmaceutical Biotechnology Lab, School of Biology and Center of Excellence in Phylogeny of Living Organisms, College of Science, University of Tehran, 14155-6455 Tehran, Iran. ^[2] Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K. ^[3] Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Station 19, 1015 Lausanne, Switzerland. ^[4] Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.;School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham B15 2TT, U.K. ^[5] Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, 38124 Braunschweig, Germany.;Technical University of Braunschweig, 38106 Braunschweig, Germany. ^[6] Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, 38124 Braunschweig, Germany.;Technical University of Braunschweig, 38106 Braunschweig, Germany.;German Centre of Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124 Braunschweig, Germany. ^[7] Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.;Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry CV4 7AL, U.K.;Department of Biochemistry and Molecular Biology, Monash University, Clayton VIC 3168, Australia.;ARC Centre of Excellence for Innovations in Peptide and Protein Science, Monash University, Clayton VIC 3168, Australia. ^[8]

关键词 6-deoxysugar RiPP antibiotic cytochrome P450 glycosyl transferase

主题词结核分枝杆菌(Mycobacterium tuberculosis);人类(Humans);结核, 抗多种药物性(Tuberculosis, Multidrug-Resistant);多基因族(Multigene Family);微生物敏感性试验(Microbial Sensitivity Tests);抗结核药(Antitubercular Agents);耐甲氧西林金黄色葡萄球菌(Methicillin-Resistant Staphylococcus aureus);糖基化(Glycosylation);放线细菌纲(Actinobacteria);生物合成途径(Biosynthetic Pathways);肽类(Peptides)

DOI 10.1021/acsinfecdis.4c00502

PMID 39189814

发布时间 2024-12-04

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ACS infectious diseases

2024年10卷9期

3378-3391页

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Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis.

ACS infectious diseases

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Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis.

ACS infectious diseases

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ACS infectious diseases

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