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Identification of Small-Molecule Antagonists Targeting the Growth Hormone Releasing Hormone Receptor (GHRHR).

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第一作者： Minos-Timotheos,Matsoukas

第一单位： University of West Attica, Department of Biomedical Engineering, Athens 12243, Greece.

作者： Minos-Timotheos,Matsoukas ^[1] ; Tarryn,Radomsky ^[2] ; Vasilis,Panagiotopoulos ^[1] ; Robin du,Preez ^[2] ; Michail,Papadourakis ^[3] ; Konstantinos,Tsianakas ^[1] ; Robert P,Millar ^[4] ; Ross C,Anderson ^[2] ; Georgios A,Spyroulias ^[5] ; Claire L,Newton ^[6]

作者单位： University of West Attica, Department of Biomedical Engineering, Athens 12243, Greece. ^[1] Centre for Neuroendocrinology, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Gezina, Pretoria 0031, South Africa.;Department of Physiology, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Gezina, Pretoria 0031, South Africa. ^[2] Cloudpharm PC, Athens 15125, Greece. ^[3] Centre for Neuroendocrinology, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Gezina, Pretoria 0031, South Africa.;Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9JZ, U.K.;Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.;School of Medicine, University of St Andrews, St Andrews KY16 9TF, U.K. ^[4] University of Patras, School of Health Sciences, Department of Pharmacy, University Campus, Rion, Patras 26500, Greece. ^[5] Centre for Neuroendocrinology, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Gezina, Pretoria 0031, South Africa.;Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9JZ, U.K. ^[6]

医学主题词人类(Humans);受体, 垂体激素调节激素(Receptors, Pituitary Hormone-Regulating Hormone);受体, 神经肽(Receptors, Neuropeptide);小分子化合物库(Small Molecule Libraries);环AMP(Cyclic AMP);药物发现(Drug Discovery)

DOI 10.1021/acs.jcim.4c00577

PMID 39207455

发布时间 2024-09-27

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