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首页> Molecular immunology> Acidity induces durable enhancement of T<sub>reg</sub> cell suppressive functions for tumor immune evasion.

Acidity induces durable enhancement of T<sub>reg</sub> cell suppressive functions for tumor immune evasion.

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作者： Nikita L,Mani ^[1] ; Samuel E,Weinberg ^[2] ; Shuvam,Chaudhuri ^[3] ; Elena,Montauti ^[4] ; Amy,Tang ^[1] ; Radhika,Iyer ^[1] ; Deyu,Fang ^[5]

作者单位： Department of Pathology, Northwestern University, USA; Center for Human Immunobiology, Northwestern University, USA. ^[1] Department of Pathology, Northwestern University, USA; Center for Human Immunobiology, Northwestern University, USA. Electronic address: Samuel-Weinberg@northwestern.edu. ^[2] Department of Pathology, Northwestern University, USA. ^[3] Department of Pathology, Northwestern University, USA; Department of Medicine Hematology and Oncology, University of California San Francisco, USA. ^[4] Department of Pathology, Northwestern University, USA; Center for Human Immunobiology, Northwestern University, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern Medicine, USA. Electronic address: fangd@northwestern.edu. ^[5]

关键词 Acidity Formate Lactate Oxidative phosphorylation Suppression T(reg) cells

主题词 T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);动物(Animals);肿瘤微环境(Tumor Microenvironment);肿瘤逃逸(Tumor Escape);小鼠(Mice);乳酸(Lactic Acid);氢离子浓度(Hydrogen-Ion Concentration);小鼠, 近交C57BL(Mice, Inbred C57BL);叉头转录因子类(Forkhead Transcription Factors);糖酵解(Glycolysis);肿瘤(Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);女(雌)性(Female)

DOI 10.1016/j.molimm.2024.08.004

PMID 39213947

发布时间 2025-01-04

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Molecular immunology

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