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IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.

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第一作者： Radhika,Joshi

第一单位： Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA.

作者： Radhika,Joshi ^[1] ; Veronika,Brezani ^[1] ; Gabrielle M,Mey ^[2] ; Sergi,Guixé-Muntet ^[3] ; Marti,Ortega-Ribera ^[1] ; Yuan,Zhuang ^[1] ; Adam,Zivny ^[1] ; Sebastian,Werneburg ^[2] ; Jordi,Gracia-Sancho ^[4] ; Gyongyi,Szabo ^[5]

作者单位： Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA. ^[1] Department of Opthalmology and Visual Sciences, Kellogg Eye Center Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA.;Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA. ^[2] Liver Vascular Biology, IDIBAPS Biomedical Research Institute-CIBEREHD, Barcelona, Spain. ^[3] Liver Vascular Biology, IDIBAPS Biomedical Research Institute-CIBEREHD, Barcelona, Spain.;Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. ^[4] Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA. gszabo1@bidmc.harvard.edu. ^[5]

关键词 APOE ARM Alzheimer’s disease Amyloid beta DAM IRF3 IRM Neuroinflammation Type 1 interferon ZBP1

医学主题词干扰素调节因子3(Interferon Regulatory Factor-3);动物(Animals);阿尔茨海默病(Alzheimer Disease);小鼠(Mice);小神经胶质细胞(Microglia);脂多糖类(Lipopolysaccharides);小鼠, 近交C57BL(Mice, Inbred C57BL);基因表达调控(Gene Expression Regulation);细胞, 培养的(Cells, Cultured);人类(Humans);小鼠, 基因敲除(Mice, Knockout)

DOI 10.1186/s12974-024-03203-7

PMID 39215356

发布时间 2024-09-04

基金项目

R01 AA017729/AA/NIAAA NIH HHS/United States R01 AG072899/AG/NIA NIH HHS/United States R01AG072899/NH/NIH HHS/United States 5R01AA017729/AA/NIAAA NIH HHS/United States

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