Prolonged, staged, and self-regulated methotrexate release coupled with ROS scavenging in an injectable hydrogel for rheumatoid arthritis therapy.

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第一作者： Mingsheng,Xu

第一单位： School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei 230026, China; CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.

作者： Mingsheng,Xu ^[1] ; Tingting,Fu ^[2] ; Chenhui,Zhang ^[2] ; Zhen,An ^[1] ; Jincong,Yan ^[1] ; Zhongzhong,Lu ^[1] ; Hanfei,Wu ^[1] ; Jihuan,Liu ^[1] ; Lei,Qiu ^[3] ; Lei,Shi ^[4] ; Jun,Lin ^[5] ; Yi,Cao ^[6] ; Renjun,Pei ^[7]

作者单位： School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei 230026, China; CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China. ^[1] Department of Orthopaedics, The Fourth Affiliated of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou 215001, China. ^[2] CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China. ^[3] Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan 215300, China. ^[4] Department of Orthopaedics, The Fourth Affiliated of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou 215001, China. Electronic address: linjun@suda.edu.cn. ^[5] CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China; Jiangxi Institute of Nanotechnology, Nanchang 330200, China. Electronic address: ycao2014@sinano.ac.cn. ^[6] School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei 230026, China; CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China. Electronic address: rjpei2011@sinano.ac.cn. ^[7]

关键词 Injectable hydrogel Mesoporous polydopamine nanoparticle Methotrexate Reactive oxygen species Rheumatoid arthritis