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A randomized, open-label, clinical trial examined the effects of canagliflozin on albuminuria and eGFR decline using an individual pre-intervention eGFR slope.

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作者单位: Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan; Department of Internal Medicine, Innoshima General Hospital, Onomichi, Japan. Electronic address: s1miyamoto@okayama-u.ac.jp. [1] Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address: h.j.lambers.heerspink@umcg.nl. [2] Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [3] Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan. [4] Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan. [5] Suzuki Diadetes Clinic, Atsugi, Japan. [6] Department of Diabetes and Endocrinology, National Hospital Organization Fukuyama Medical Center, Fukuyama, Japan. [7] Diabetes Internal Medicine, Sumitomo Besshi Hospital, Nihama, Japan. [8] Department of Diabetic Medicine, Kurashiki Central Hospital, Kurashiki, Japan. [9] Department of Diabetes and Endocrinology, Takamatsu Hospital, Takamatsu, Japan. [10] Department of Diabetology and Metabolism, National Hospital Organization Okayama Medical Center, Okayama, Japan. [11] Department of Internal Medicine Diabetic Center, Okayama City Hospital, Okayama, Japan. [12] Division of Diabetes and Metabolism, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan. [13] Department of Diabetes, Ochiai General Hospital, Maniwa, Japan. [14] Department of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, Japan; Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, Japan. [15] Department of Diabetes and Endocrinology, Kochi Health Sciences Center, Kochi, Japan. [16] Nunoue Clinic, Tsuyama, Japan. [17] Internal Medicine, Osafune Clinic, Setouchi, Japan. [18] Department of Diabetes and Endocrinology, Matsue City Hospital, Matsue, Japan. [19] Diabetes Center, Okayama Saiseikai General Hospital, Okayama, Japan. [20] Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University Kashiwa Hospital, Kashiwa, Japan. [21] Department of Endocrinology and Diabetes, Fukuoka University School of Medicine, Fukuoka, Japan. [22] Department of Nephrology and Laboratory Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan. [23] Department of Hygiene, Faculty of Medicine, Kagawa University, Miki, Kagawa, Japan. [24]
DOI 10.1016/j.kint.2024.08.019
PMID 39216659
发布时间 2024-10-20
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