Tviblindi algorithm identifies branching developmental trajectories of human B-cell development and describes abnormalities in RAG-1 and WAS patients.

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作者： Marina,Bakardjieva ^[1] ; Ondřej,Pelák ^[1] ; Marjolein,Wentink ^[2] ; Hana,Glier ^[1] ; David,Novák ^[3] ; Jitka,Stančíková ^[1] ; Daniela,Kužílková ^[4] ; Ester,Mejstříková ^[4] ; Iga,Janowska ^[5] ; Marta,Rizzi ^[5] ; Mirjam,van der Burg ^[6] ; Jan,Stuchlý ^[4] ; Tomáš,Kalina ^[4]

作者单位： CLIP, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic. ^[1] Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. ^[2] CLIP, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.;Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.;Data Mining and Modeling for Biomedicine, Center for Inflammation Research, VIB-UGent, Ghent, Belgium. ^[3] CLIP, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.;Department of Paediatric Haematology and Oncology, University Hospital Motol, Prague, Czech Republic. ^[4] Department of Rheumatology and Clinical Immunology, Freiburg University Medical Center, University of Freiburg, Freiburg, Germany.;Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. ^[5] Department of Pediatrics, Laboratory for Pediatric Immmunology, Leiden University Medical Center, Leiden, the Netherlands. ^[6]

关键词 B‐cell development CD73 Mass cytometry RAG‐1 Trajectory inference WAS

主题词人类(Humans);B-淋巴细胞(B-Lymphocytes);同源盒结构域蛋白质类(Homeodomain Proteins);细胞分化(Cell Differentiation);算法(Algorithms);突变(Mutation)

DOI 10.1002/eji.202451004

PMID 39235410

发布时间 2024-12-12

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