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Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2.

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第一作者: Wenjie,Li
第一单位: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai, 200237, China.
作者: Wenjie,Li [1] ; Wenyi,Mei [1] ; Hewei,Jiang [2] ; Jie,Wang [1] ; Xiaoli,Li [3] ; Lina,Quan [1] ; Yanyan,Diao [1] ; Yanni,Ma [4] ; Sisi,Fan [1] ; Zhuwei,Xie [1] ; Mengdie,Gong [1] ; Huan,Zhu [1] ; Dewen,Bi [3] ; Feng,Zhang [5] ; Lei,Ma [1] ; Jian,Zhang [1] ; Yufeng,Gao [6] ; Aris,Paschalidis [7] ; Honghuang,Lin [7] ; Fangfang,Liu [8] ; Kangdong,Liu [8] ; Mingliang,Ye [4] ; Zhenjiang,Zhao [1] ; Yajun,Duan [5] ; Zhuo,Chen [1] ; Yufang,Xu [1] ; Weilie,Xiao [9] ; Shengce,Tao [10] ; Lili,Zhu [11] ; Honglin,Li [12]
作者单位: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai, 200237, China. [1] Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, 200240, China.;Lingang Laboratory, Shanghai, 200031, China. [2] Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500, China. [3] CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R & A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. [4] Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China. [5] Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. [6] Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01655, USA. [7] Department of Pathophysiology, School of Basic Medical Sciences, Academy of Medical Science, College of Medicine, Zhengzhou University, Zhengzhou, 450001, China. [8] Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500, China. xiaoweilie@ynu.edu.cn. [9] Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, 200240, China. taosc@sjtu.edu.cn. [10] Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai, 200237, China. zhulfl@ecust.edu.cn. [11] Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai, 200237, China. hlli@ecust.edu.cn.;Innovation Center for AI and Drug Discovery, East China Normal University, Shanghai, 200062, China. hlli@ecust.edu.cn.;Lingang Laboratory, Shanghai, 200031, China. hlli@ecust.edu.cn. [12]
DOI 10.1007/s11427-024-2706-2
PMID 39235560
发布时间 2025-01-02
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Science China. Life sciences

Science China. Life sciences

2025年68卷1期

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