首页> International journal of biological macromolecules> Formulating a TMEM176B blocker in chitosan nanoparticles uncouples its paradoxical roles in innate and adaptive antitumoral immunity.

Formulating a TMEM176B blocker in chitosan nanoparticles uncouples its paradoxical roles in innate and adaptive antitumoral immunity.

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第一作者： Sabina,Victoria

第一单位： Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.

作者： Sabina,Victoria ^[1] ; Analía,Castro ^[2] ; Alvaro,Pittini ^[3] ; Daniela,Olivera ^[4] ; Sofía,Russo ^[4] ; Ignacio,Cebrian ^[5] ; Alvaro W,Mombru ^[2] ; Eduardo,Osinaga ^[3] ; Helena,Pardo ^[6] ; Mercedes,Segovia ^[7] ; Marcelo,Hill ^[8]

作者单位： Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay. ^[1] Centro NanoMat, Instituto Polo Tecnológico de Pando, Facultad de Química, UdelaR, Camino Aparicio Saravia s/n, 9100 Pando, Canelones, Uruguay. ^[2] Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay; Laboratory of Tumor Immunology and Glycobiology, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay. ^[3] Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay; Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay. ^[4] Facultad de Ciencias Médicas, Instituto de Histología y Embriología de Mendoza (IHEM)-CONICET/Universidad Nacional de Cuyo, Mendoza, Argentina. ^[5] Centro NanoMat, Instituto Polo Tecnológico de Pando, Facultad de Química, UdelaR, Camino Aparicio Saravia s/n, 9100 Pando, Canelones, Uruguay. Electronic address: hpardo@fq.edu.uy. ^[6] Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay; Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay. Electronic address: msegovia@pasteur.edu.uy. ^[7] Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay; Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay. Electronic address: mhill@pasteur.edu.uy. ^[8]

关键词 Chitosan nanoparticles Cross-presentation Inflammasome Nanoencapsulation TMEM176B Tumor immunity