Design, synthesis and antimycobacterial activity of novel benzothiazinones with improved water solubility.

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作者： Xijun,Zhong ^[1] ; Jizhou,Wu ^[1] ; Na,Du ^[1] ; Sheng,Zhou ^[2] ; Chao,Ma ^[3] ; Tiezheng,Xue ^[2] ; Meng,Wei ^[1] ; Jiaqi,Gong ^[1] ; Bin,Wang ^[4] ; Mingliang,Liu ^[1] ; Apeng,Wang ^[5] ; Kai,Lv ^[6] ; Yu,Lu ^[7]

作者单位： Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. ^[1] Hebei Medical University, Shijiazhuang, 050017, China. ^[2] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; MindRank AI Ltd., Hangzhou, 310000, China. ^[3] Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital College of Pharmacy, Medical University, Beijing, 100149, China. ^[4] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: wangapengbuct@126.com. ^[5] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: lvkailk@hotmail.com. ^[6] Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital College of Pharmacy, Medical University, Beijing, 100149, China. Electronic address: luyu4876@hotmail.com. ^[7]

关键词 Antimycobacterial activity Nitrobenzothiazinones Synthesis Water solubility