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Altering glycopeptide antibiotic biosynthesis through mutasynthesis allows incorporation of fluorinated phenylglycine residues.

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第一作者: Irina,Voitsekhovskaia
第一单位: Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine Tübingen, University of Tübingen Tübingen Germany evi.stegmann@uni-tuebingen.de.
作者单位: Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine Tübingen, University of Tübingen Tübingen Germany evi.stegmann@uni-tuebingen.de. [1] Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University Clayton VIC 3800 Australia max.cryle@monash.edu.;EMBL Australia, Monash University Clayton VIC 3800 Australia.;ARC Centre of Excellence for Innovations in Peptide and Protein Science Australia. [2] Institute of Organic Chemistry, University of Tübingen Tübingen Germany. [3] Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn Bonn Germany. [4] ARC Centre of Excellence for Innovations in Peptide and Protein Science Australia.;Research School of Chemistry, The Australian National University Acton ACT 2601 Australia. [5] Monash Proteomics and Metabolomics Platform, Monash University Clayton VIC 3800 Australia. [6] Microbiology/Biotechnology, Interfaculty Institute of Microbiology and Infection Medicine Tübingen, University of Tübingen Tübingen Germany. [7] Institute of Organic Chemistry, University of Tübingen Tübingen Germany.;Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn Bonn Germany. [8] Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine Tübingen, University of Tübingen Tübingen Germany evi.stegmann@uni-tuebingen.de.;ARC Centre of Excellence for Innovations in Peptide and Protein Science Australia.;German Centre for Infection Research (DZIF), Partner Site Tübingen Tübingen Germany.;Cluster of Excellence 'Controlling Microbes to Fight Infections' (CMFI), University of Tübingen Tübingen Germany. [9]
DOI 10.1039/d4cb00140k
PMID 39247680
发布时间 2024-09-10
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