Optimizing Nav1.7-Targeted Analgesics: Revealing Off-Target Effects of Spider Venom-Derived Peptide Toxins and Engineering Strategies for Improvement.

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第一作者： Sen,Luo

第一单位： The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.;Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.;Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China.

作者： Sen,Luo ^[1] ; Xi,Zhou ^[1] ; Meijing,Wu ^[1] ; Gongxin,Wang ^[2] ; Li,Wang ^[1] ; Xujun,Feng ^[1] ; Hang,Wu ^[1] ; Ren,Luo ^[1] ; Minjuan,Lu ^[1] ; Junxian,Ju ^[1] ; Wenxing,Wang ^[1] ; Lei,Yuan ^[1] ; Xiaoqing,Luo ^[1] ; Dezheng,Peng ^[3] ; Li,Yang ^[1] ; Qingfeng,Zhang ^[1] ; Minzhi,Chen ^[1] ; Songping,Liang ^[1] ; Xiuming,Dong ^[4] ; Guoliang,Hao ^[5] ; Yunxiao,Zhang ^[3] ; Zhonghua,Liu ^[1]

作者单位： The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.;Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.;Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China. ^[1] Henan Academy of Innovations in Medical science, Institute of Electrophysiology, Zhengzhou, Henan, 450000, China. ^[2] Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials, School of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006, China. ^[3] Department of Research, Scope Research Institute of Electrophysiology, Kaifeng, 475004, China. ^[4] Henan Academy of Innovations in Medical science, Institute of Electrophysiology, Zhengzhou, Henan, 450000, China.;Department of Research, Scope Research Institute of Electrophysiology, Kaifeng, 475004, China. ^[5]

关键词 Kv4.2 and Kv4.3 Nav1.7 analgesic off‐target spider venom‐derived peptide toxins

主题词蜘蛛毒液类(Spider Venoms);动物(Animals);镇痛药(Analgesics);小鼠(Mice);疾病模型, 动物(Disease Models, Animal);肽类(Peptides);人类(Humans)

DOI 10.1002/advs.202406656

PMID 39248322

发布时间 2024-11-15

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024年11卷42期

e2406656页

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Optimizing Nav1.7-Targeted Analgesics: Revealing Off-Target Effects of Spider Venom-Derived Peptide Toxins and Engineering Strategies for Improvement.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Optimizing Nav1.7-Targeted Analgesics: Revealing Off-Target Effects of Spider Venom-Derived Peptide Toxins and Engineering Strategies for Improvement.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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