首页> Journal of neurology> Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank.

Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank.

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第一作者： Weijia,Jin

第一单位： Department of Biostatistics, University of Florida, Gainesville, FL, 32603, USA.

作者： Weijia,Jin ^[1] ; Jonathan,Boss ^[2] ; Kelly M,Bakulski ^[3] ; Stephen A,Goutman ^[4] ; Eva L,Feldman ^[4] ; Lars G,Fritsche ^[5] ; Bhramar,Mukherjee ^[6]

作者单位： Department of Biostatistics, University of Florida, Gainesville, FL, 32603, USA. ^[1] Department of Biostatistics, University of Michigan, University of Michigan, Ann Arbor, MI, 48109, USA.;Center for Precision Health Data Science, University of Michigan, Ann Arbor, MI, 48109, USA. ^[2] Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA. ^[3] Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA. ^[4] Department of Biostatistics, University of Michigan, University of Michigan, Ann Arbor, MI, 48109, USA. larsf@umich.edu.;Center for Precision Health Data Science, University of Michigan, Ann Arbor, MI, 48109, USA. larsf@umich.edu. ^[5] Department of Biostatistics, University of Michigan, University of Michigan, Ann Arbor, MI, 48109, USA. bhramar@umich.edu.;Center for Precision Health Data Science, University of Michigan, Ann Arbor, MI, 48109, USA. bhramar@umich.edu.;Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA. bhramar@umich.edu.;Michigan Institute for Data Science, University of Michigan, Ann Arbor, MI, 48109, USA. bhramar@umich.edu. ^[6]

关键词 Amyotrophic lateral sclerosis (ALS)Phenotypic risk scores Polygenic risk scores UK biobank