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Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes.

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第一作者: Kurt,Farrell
第一单位: Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
作者单位: Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [1] Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Genetics & Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [2] Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. [3] Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [4] Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [5] Department of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.;Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [6] Department of Neurology, Ludwig-Maximilians-Universität Hospital, Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. [7] Institute of Human Genetics, Justus-Liebig University Giessen, 35392, Giessen, Germany. [8] Department of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.;CurePSP, Inc., New York, NY, USA. [9] Department of Clinical and Movement Neurosciences, University College London, London, UK.;Queen Square Institute of Neurology, University College London, London, UK. [10] Queen Square Institute of Neurology, University College London, London, UK.;Dementia Research Institute, University College London, London, UK. [11] Queen Square Institute of Neurology, University College London, London, UK.;Queen Square Brain Bank for Neurological Disorders, University College London, London, UK. [12] Department of Clinical and Movement Neurosciences, University College London, London, UK.;Queen Square Institute of Neurology, University College London, London, UK.;Queen Square Brain Bank for Neurological Disorders, University College London, London, UK. [13] VIB Center for Molecular Neurology, University of Antwerp, Antwerp, Belgium.;Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.;Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. [14] Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. [15] Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [16] Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.;Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.;Program in Neurogenetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.;Center for Autism Research and Treatment Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.;Institute for Precision Health, University of California, Los Angeles, CA, USA. [17] Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. John.crary@mountsinai.org.;Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. John.crary@mountsinai.org.;Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. John.crary@mountsinai.org.;Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA. John.crary@mountsinai.org.;Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. John.crary@mountsinai.org.;Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, USA. John.crary@mountsinai.org. [18] Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Adamnaj@pennmedicine.upenn.edu.;Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Adamnaj@pennmedicine.upenn.edu.;Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Adamnaj@pennmedicine.upenn.edu. [19]
DOI 10.1038/s41467-024-52025-x
PMID 39251599
发布时间 2024-11-16
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