Reduction of butyrate-producing bacteria in the gut microbiome of Japanese patients with pancreatic cancer.

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作者： Makoto,Sono ^[1] ; Kei,Iimori ^[1] ; Munemasa,Nagao ^[1] ; Satoshi,Ogawa ^[1] ; Takahisa,Maruno ^[1] ; Yuki,Nakanishi ^[1] ; Takayuki,Anazawa ^[2] ; Kazuyuki,Nagai ^[2] ; Toshihiko,Masui ^[2] ; Hiroshi,Mori ^[3] ; Koji,Hosomi ^[4] ; Jun,Kunisawa ^[4] ; Haruka,Yokota ^[5] ; Yoshiki,Tanaka ^[5] ; Hiroshi,Ohno ^[5] ; Etsuro,Hatano ^[2] ; Akihisa,Fukuda ^[6] ; Hiroshi,Seno ^[1]

作者单位： Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. ^[1] Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. ^[2] Department of Informatics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka, 411-8540, Japan. ^[3] Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Asagi, Ibaraki, Osaka, 567-0085, Japan. ^[4] Biofermin Pharmaceutical Co., Ltd., 7-3-4 Higashi-machi, Ibukidai, Nishi-ku, Kobe, 651-2242, Japan. ^[5] Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. Electronic address: fukuda26@kuhp.kyoto-u.ac.jp. ^[6]

关键词 Butyrate-producing bacteria Dysbiosis Gut microbiome Microbial signature Oral microbiome Pancreatic cancer Short-chain fatty acid