Discovery of <i>N</i>-Aryl-<i>N</i>'-[4-(aryloxy)cyclohexyl]squaramide-Based Inhibitors of LXR/SREBP-1c Signaling Pathway Ameliorating Steatotic Liver Disease: Navigating the Role of SIRT6 Activation.
作者:
主题词
人类(Humans);胆固醇调节元件结合蛋白质1(Sterol Regulatory Element Binding Protein 1);动物(Animals);信号传导(Signal Transduction);Hep G2细胞(Hep G2 Cells);抗衰老酶(Sirtuins);小鼠(Mice);脂肪肝(Fatty Liver);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);构效关系(Structure-Activity Relationship);药物发现(Drug Discovery)
DOI
10.1021/acs.jmedchem.4c01597
PMID
39259827
发布时间
2024-10-10
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Journal of medicinal chemistry
17608-17628页
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