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An improved approach to generate IL-15+/+/TGFβR2-/- iPSC-derived natural killer cells using TALEN.

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第一作者： An-Ping,Chen

第一单位： Cytovia Therapeutics, Inc., Natick, MA, USA. Electronic address: anping.chen@cytoviatx.com.

作者： An-Ping,Chen ^[1] ; Peng,Gao ^[2] ; Liang,Lin ^[2] ; Preeti,Ashok ^[2] ; Hongzhi,He ^[2] ; Chao,Ma ^[2] ; David Li,Zou ^[2] ; Vincent,Allain ^[3] ; Alex,Boyne ^[4] ; Alexandre,Juillerat ^[4] ; Philippe,Duchateau ^[5] ; Armin,Rath ^[6] ; Daniel,Teper ^[6] ; Antonio,Arulanandam ^[2] ; Hao-Ming,Chang ^[2] ; Justin,Eyquem ^[7] ; Wei,Li ^[8]

作者单位： Cytovia Therapeutics, Inc., Natick, MA, USA. Electronic address: anping.chen@cytoviatx.com. ^[1] Cytovia Therapeutics, Inc., Natick, MA, USA. ^[2] Gladstone-University of California, San Francisco Institute of Genomic Immunology, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Université Paris Cité, INSERM UMR976, Hôpital Saint-Louis, Paris, France. ^[3] Cellectis Inc, New York, NY, USA. ^[4] Cellectis, Paris, France. ^[5] Cytovia Therapeutics, Inc., Aventura, FL, USA. ^[6] Gladstone-University of California, San Francisco Institute of Genomic Immunology, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. ^[7] Cytovia Therapeutics, Inc., Natick, MA, USA. Electronic address: wei.li@cytoviatx.com. ^[8]

关键词 B2M CP: cancer biology GUIDE-seq TALEN TGFβR2 anti-tumor beta-2-microglobulin gene editing human induced pluripotent stem cells iPSC-derived cell therapies iPSCs interleukin-15 natural killer cells

医学主题词诱导多能干细胞(Induced Pluripotent Stem Cells);杀伤细胞, 天然(Killer Cells, Natural);白细胞介素15(Interleukin-15);人类(Humans);细胞分化(Cell Differentiation)

DOI 10.1016/j.crmeth.2024.100857

PMID 39260365

发布时间 2024-11-13

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